James C. Matthews, Ph.D.
Dept. of Animal and Food Sciences
213 W. P. Garrigus Building
University of Kentucky
Lexington, KY 40546-0215
Telephone: (859) 257-7513
Telefax: (859) 257-5318
1995 – 1997 Post-doc.
Univ. Florida College of Medicine: Joint appointment in Biochemistry & Molecular Biology/Pediatrics–Gastroenterology
1995 Ph.D. Virginia Tech Major: Animal Science 1992 M.S. Virginia Tech Major: Animal Science 1988 B.S. Rutgers University Major: Animal Science (minor: Nutrition)
PROFESSIONAL APPOINTMENTS (as a University of Kentucky faculty member)
2008 – 2011
Adjunct Associate Professor, Department of Animal and Poultry Sciences, University of Guelph, Guelph, Ontario
2007 – present
UK-Alltech Professor of Applied Nutritional Sciences
2004 – present Associate Professor, Department of Animal Sciences, Univ. of Kentucky 1998 – 2003
Assistant Professor, Department of Animal Sciences, Univ. of Kentucky
Graduate - Developed and teach “Physiology of Digestion and Nutrient Absorption” (3 credits, 7 semesters)
Graduate - Developed and teach “Protein Metabolism” (2 credits, 7 semesters).
Undergraduate - Instruction: Course coordinator (17 semesters) for over 190 Agricultural Biotechnology Independent Undergraduate Research projects (3 credit hours or more). Research: Very active in undergraduate research: sponsored 56 credit hours of undergraduate research in my lab.
Graduate Faculty (as sole advisor)
Completed: 6 M.S. and 2 Ph.D. students, and 4 postdoctoral fellowships
Current: 1 M.S. and 1 Ph.D. students
Reviewer Service (1998 - present)
Journals - Editorial Board Member: J. Anim. Sci. (2001-2004); Ad hoc reviewer: J. Animal Science, J. Dairy Science, J. Biological Chemistry, American J. Physiology, J. Nutrition, J. Nutritional Biochemistry, FEBS Letters, J. Veterinary Medicine, CAST
Grants- Review Panel Member: USDA NIFA Competitive Grants Program; Ad hoc Reviewer: USDA-NRICGP, The Wellcome Trust, USDA-BARD.
Critical University of Kentucky Committee Service
Agriculture Biotechnology Program Coordinating Comm. (1999 - present); University Radiation Safety Comm. (2002 - 2008); University Biological Safety Comm. (2008 – 2011).
Conceived, organized, and sponsored (as the University of Kentucky-Alltech Professor of Applied Nutritional Sciences), 4 workshops (experimental design, RNA processing, RNA-silencing, bioinformatic analysis, and statistical analyses), nine seminars, and two symposiums on nutrigenomics and/or epigenetics, by leading researchers from Univ. of Illinois, Penn State Univ., Univ. California, The Ohio State Univ., Texas A&M Univ., NIH/NCI, Univ. Texas Health Science Center San Antonio, INRA, and Queen’s Medical Centre. Over 1,200 undergraduate and graduate students, postdoctoral fellows, and faculty from Univ. of Kentucky, Eastern Kentucky Univ., and private industry groups attended these presentations.
RECENT REFEREED MANUSCRIPTS (of 46)
J. L. Klotz, K. R. Brown, Y. Xue, J. C. Matthews, J. A. Boling, W. R. Burris, L. P. Bush, and J. R. Strickland. 2012. Alterations in Serotonin Receptor-induced Contractility of Bovine Lateral Saphenous Vein in Cattle Grazing Endophyte-infected Tall Fescue. Journal of Animal Science 90:682-693.
E. D. Miles, Y. Xue, J. R. Strickland, J. A. Boling, and J. C. Matthews. 2011. Ergopeptines Bromocriptine and Ergovaline, and Domperidone, Inhibit Bovine Equilibrative Nucleoside Transporter 1-like Activity. Journal of Agriculture and Food Chemistry. 59:9691-9699.
Y. Xue, J. R. Strickland, J. A. Boling, J. C. Matthews. 2011. Bovine Vesicular Glutamate Transporter Activity Is Inhibited by Ergovaline and Other Ergopeptines. Journal of Dairy Science 94:3331-3341.
J. R. Strickland, M. L. Looper, J. C. Matthews, C. F. Rosenkrans, M. D. Flythe, and K. R. Brown. 2011. BOARD-INVITED REVIEW: St. Anthony’s Fire in Livestock: Causes, Mechanisms and Potential Solution. Journal of Animal Science 89:1603-1626.
K. R. Brown, G. A. Anderson, K. Son, G. Rentfrow, L. P. Bush, J. L. Klotz, J. R. Strickland, J. A. Boling, and J. C. Matthews. 2009. Growing Steers Grazing High versus Low Endophyte (Neotyphodium coenophialum)-infected Tall Fescue Have Reduced Serum Enzymes, Increased Hepatic Glucogenic Enzymes, and Reduced Liver and Carcass Mass. Journal of Animal Science 87:748-760.
K. M. Brennan, W. R. Burris, J. A. Boling and J. C. Matthews. 2011. Selenium Content in Blood Fractions and Liver of Beef Heifers is Greater with a Mix of Inorganic/Organic or Organic Versus Inorganic Supplemental Selenium Forms but the Time Required for Maximal Assimilation is Tissue-specific. Biological Trace Mineral Research, 144:504-516.
S. F. Liao, K. R. Brown, A. J. Stromberg, W. R. Burris, J. A. Boling, and J. C. Matthews. 2010. Dietary Supplementation of Selenium in Inorganic and Organic Forms Differentially and Commonly Alters Blood and Liver Selenium Concentrations and Liver Gene Expression Profiles of Growing Beef Heifers Biological Trace Element Research 140:151-169.
M. Steele, G. Vandervoort, O. AlZahal, S. Hook, J. C. Matthews, and B. W. McBride. 2011. Rumen Epithelial Adaptation to High Grain Diets Involves the Coordinated Regulation of Genes Involved in Cholesterol Homeostasis. Physiological Genomics 43:308-316.
Y. Xue, S. F. Liao, K. Son, S. L. Greenwood, B. W. McBride, J. A. Boling, and J. C. Matthews. 2010. Metabolic Acidosis in Sheep Alters Expression of Renal and Skeletal Muscle Amino Acid Enzymes and Transporters. Journal of Animal Science 88:707-717.
N. E. Odongo, S. L. Greenwood, M. M. Or-Rashid, O. AlZahal, A. K. Shoveller, M. I. Lindinger, J. C. Matthews, and B. W. McBride. 2009. Effects of Nutritionally Induced Metabolic Acidosis With or Without Glutamine Infusion on Acid-base Balance, Plasma Amino Acids and Plasma Non-esterified Fatty Acids in Sheep. Journal of Animal Science 87:1077-1084.
S. L. Greenwood, O. AlZahal, K. C. Swanson, J. C. Matthews, and B. W. McBride. 2009. Influence of Glutamine Infusion on Ubiquitin, Caspase-3, Cathepsins L and B, and m-Calpain Expression in Sheep with Nutritionally Induced Metabolic Acidosis. Journal of Animal Science 87:2073-2079.
C. C. Taylor-Edwards, D. G. Burrin, J. C. Matthews, K. R. McLeod, J. J. Holst, and D. L. Harmon. 2010. Expression of mRNA for Proglucagon and Glucagon-like Peptide-2 (GLP-2) Receptor in the Ruminant Gastrointestinal Tract and the Influence of Energy Intake. Domestic Animal Endocrinology, 39:181-193.
S. F. Liao, D. L. Harmon, E. S. Vanzant, K. R. McLeod, J. A. Boling, and J. C. Matthews. 2010. The Small Intestinal Epithelia of Beef Steers Differentially Express Sugar Transporter mRNA in Response to Abomasal vs Ruminal Infusion of Starch Hydrolysate. Journal of Animal Science 88:306-314.
S. F. Liao, E. S. Vanzant, D. L. Harmon, K. R. McLeod, J. A. Boling, and J. C. Matthews. 2009. Ruminal and Abomasal Starch Hydrolysate Infusions Selectively Decrease the Expression of Cationic Amino Acid Transporter mRNA by Small Intestinal Epithelia of Forage-fed Beef Steers. Journal of Dairy Science 92:1124-1135.
S. F. Liao, J. S. Monegue, M. D. Lindemann, G. L. Cromwell, and J. C. Matthews. 2010. Dietary Supplementation of Boron Differentially Affects Expression of Borate Transporter (NaBC1) mRNA by Jejunum and Kidney of Growing Pigs. Biological Trace Element Research 143:901-912.
RECENT REFEREED ABSTRACTS (of 75)
J. C. Matthews, D. C. Mahan, K. M. Brennan, S. F. Liao, W. R. Burris, and J. A. Boling. 2011. Mixed or Organic vs Inorganic Forms of Selenium (Se) Differentially Affect Tissue Se Concentrations of Growing Beef Heifers. J. Anim. Sci. Vol 89, E-Suppl. 2, pg 153.
P. Joseph, G. Rentfrow, L. L. Slaughter, K. M. McClelland, S. P. Suman, J. A. Boling, K. M. Brennan, J. C. Matthews. 2011. Effect of Dietary Selenium Supplementation on Color Shelf-life of Beef Psoas major Steaks from Maturing Heifers. American Meat Science Association 64th Reciprocal Meat Conference, Kansas State University, June 19-22, 2011. Meeting Program & Abstracts: pg 45.
K. M. Brennan, J. A. Boling, R. Xiao, D. Mallonee, R. F. Power, and J. C. Matthews. 2011. Effects of Supplementation of Organic, Inorganic or a 50/50 Mix of Selenium on Gene Expression Profiles in the Longissmus Dorsi Muscle of Maturing Angus Beef Heifers. Journal of Animal Science, Vol. 89, E-Suppl. 1, pg 110.
L. L. Slaughter, K. M. McClelland, S. F. Liao, K. M. Brennan, G. Rentfrow, J. A. Boling, and J. C. Matthews. 2010. The effects of dietary selenium on the shelf-life stability of Longissimus lumborum steaks from maturing heifers. American Meat Science Association 62nd Reciprocal Meats Conference Lubbock, TX. Jun 20-23. Meeting Program & Abstracts: pp. 58-59.
K. M. Brennan, W. R. Burris, J. A. Boling, and J. C. Matthews. 2010. Effects of selenium source on blood selenium content, blood cell counts and peripheral mononuclear cell mRNA profiles in maturing beef heifers. FASEB J. 24:916.4.
J. C. Matthews. 2010. Nutrient transporters in support of ruminant growth and development: novel and updated findings. J. Anim. Sci. Vol. 88, E-Suppl. 1, pg 270-271.
SELECTED INVITED BOOK CHAPTERS (of 10)
B. M. Zanghi* and J. C. Matthews. 2010. Physiological Importance and Mechanisms of Protein Hydrolysate Absorption. In: V. K. Pasupuleti and A. L. Demain (Eds.) Protein Hydrolysates in Biotechnology. Chapter 9, pages 135-177. Springer, Secaucus, New Jersey.
J. C. Matthews, and G. L. Sipe. Patterns and Putative Regulatory Mechanisms of High-Affinity Glutamate Transporter Expression by Ruminants. 2006. Proceedings of the Xth International Symposium on Ruminant Physiology, Copenhagen, Denmark. Pages 263-287.
J. C. Matthews. Expression and Function of Non-Organelle Glutamate Transporters to Support Peripheral Tissue Function. 2005. In: S. Gill and O. Pulido (Eds.) Glutamate Receptors in Peripheral Tissues: Excitatory Transmission Outside the Central Nervous System. Chapter 1, pages 1-30. Kluwer Academc/Plenum Press, New York