Bernhard Hennig, Ph.D., R.D.  Molecular and Cell Nutrition Laboratory Office: (859) 323-4933 ext. 81387 or 81343 Lab: (859) 323-4933 ext. 81375 Fax: (859) 257-1811 E-mail: bhennig@email.uky.edu

Professor of Nutrition and Toxicology; Ph.D. in Nutrition, Iowa State, 1982.

Dr. Hennig’s primary appointment is in the College of Agriculture. He also has academic appointments with the Center of Nutritional Sciences, Graduate Center for Toxicology and the Center of Membrane Sciences, and he is a member of the Gill Heart Institute.

Dr. Hennig is the current Director of the University of Kentucky Superfund Basic Research Program (http://www.uky.edu/Research/Superfund/) or http://www-apps.niehs.nih.gov/sbrp/index.cfm

Dr. Hennig is the Editor-in-Chief of the Journal of Nutritional Biochemistry (http://www.elsevier.com/locate/jnutbio)

Dr. Hennig also serves on the Editorial Boards for the Journal of the American College of Nutrition, and Nutrition Research. He is a Fellow of the American College of Nutrition, and Fellow of the Council on Arteriosclerosis, American Heart Association. Dr. Hennig also is a Council Member of the Cardiovascular Hypertension Section, American College of Nutrition.

NATIONAL AWARDS

• Fulbright Recipient, 2008; Universidad de Antioquia, Medellín, Colombia
• Helen LeBaron Hilton Award for Outstanding Leadership and Distinguished Achievement; Iowa State University, 2006
• Grace A. Goldsmith Award for Significant Current Achievements in the Field of Nutrition, 1995
• Borden Award for Significant Research in Nutrition, 1993
• Clintec Award for Excellence in the Science of Nutrition, 1993

 

RESEARCH EMPHASIS

Dr. Hennig’s research emphasis involves the utilization of tissue culture model systems in the study of nutrition and atherosclerosis, with emphasis in the role of nutrients on biochemical and molecular mechanisms of vascular endothelial cell function, injury and protection. His research has focused on the injurious effects of individual fats (e.g., fatty acids, cholesterol and their oxidation derivatives) to vascular endothelial cells and protection against such injury by certain vitamins and minerals (e.g., vitamin E and zinc). Because the nutritional environment of the vascular endothelium can influence cytokine-mediated endothelial activation or dysfunction, vascular effects of inflammatory cytokines also are being studied. In addition, Dr. Hennig is studying molecular mechanisms of nutrient interactions with the cytotoxic effects of specific environmental contaminants, such as persistent organic pollutants, in relation to endothelial cell activation and the pathology of atherosclerosis. Results from these studies may suggest novel therapeutic interventions by further understanding "endothelial cell nutrition" as a key variable in the etiology of diseases such as atherosclerosis.

RECENT PUBLICATIONS (OUT OF OVER 170)
For a complete list: PubMed

Huang, W., I.E. András, G.B. Rha, B. Hennig, and M. Toborek. 2011. PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. FASEB Journal, 25: 3979-3988.

Layne, J., Z. Majkova, M. Toborek, and B. Hennig. 2011. Emerging Issues: Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases. Journal of Nutritional Biochemistry, 22: 807-811.

Lehner, C., R. Gehwolf, H. Tempfer, I. Krizbai, B. Hennig, H.C. Bauer, and H. Bauer. 2011. Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases. Antioxidants & Redox Signaling, 15: 1305-1323.

Majkova, Z., J. Layne, M. Sunkara, A.J. Morris, M. Toborek, and B. Hennig. 2011. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Toxicology of Applied Pharmacology. 251(1): 41-49.

András, I.E., S.Y. Eum, W. Huang, Y. Zhong, B. Hennig, and M. Toborek. 2010. HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin. Molecular and Cellular Neuroscience 43:232-243.

Choi, Y.J., X. Arzuaga, C.T. Kluemper, M. Toborek, and B. Hennig. 2010. Quercetin blocks caveolae-dependent proinflammatory responses induced by co-planar PCBs. Environment International 36(8):931-4.

Choi, Y.J., M.J. Seelbach, H. Pu, S.Y. Eum, L. Chen, B. Zhang, B. Hennig, and M. Toborek. 2010. Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression. Environmental Health Perspectives 118(7):976-81.

Han, S.G., S.Y. Eum, M. Toborek, E. Smart, and B. Hennig. 2010. Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice. Toxicology and Applied Pharmacology 246(1-2):74-82.

Huang, W., G.B. Rha, L. Chen, M.J. Seelback, B. Zhang, I.A. Andras, D. Bruemmer, B. Hennig, and M. Toborek. 2010. Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial passage of HIV-1-infected cells. American Journal of Physiology - Heart and Circulatory Physiology 298(4):H1136-45.

Layne, J., Z. Majkova, M. Toborek, and B. Hennig. 2010. Emerging Issues: Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases. Journal of Nutritional Biochemistry DOI:10.1016/j.jnutbio.2010.09.013.

Majkova, Z., M. Toborek, and B. Hennig. 2010. The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants. Journal of Cellular and Molecular Medicine 14(10):2359-70.

Seelbach, M., L. Chen, A. Powell, Y.J. Choi, B. Zhang, B. Hennig, and M. Toborek. 2010. Polychlorinated biphenyls disrupt the blood-brain barrier integrity and promote brain metastasis formation. Environmental Health Perspectives 118(4):479-84.

Zhang, B., L. Chen, K.R. Swartz, D. Bruemmer, S.Y. Eum, W. Huang, M. Seelbach, Y.J. Choi, B. Hennig, and M. Toborek. 2010. Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. Journal of Neuroscience Research 88(13):2859-68.

Zheng, Y., M. Toborek, and B. Hennig. 2010. Epigallocatechin gallate-mediated protection against tumor necrosis factor-á-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent. Metabolism 59(10):1528-35.

Zhong, Y., B. Hennig, and M. Toborek. 2010. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of p-glycoprotein in brain endothelial cells. Journal of Cerebral Blood Flow & Metabolism 30(3):522-33.

Arzuaga, X., N. Ren, A. Stromberg, E.P. Black, V. Arsenescu, L.A. Cassis, Z. Majkova, M. Toborek, and B. Hennig. Induction of gene pattern changes associated with dysfunctional lipid metabolism induced by dietary fat and exposure to a persistent organic pollutant. Toxicology Letters 189: 96-101, 2009.

Eum, S.Y., I. Andras, B. Hennig, and M. Toborek. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicology and Applied Pharmacology 240: 299-305, 2009.

Huang, W., S.Y. Eum, I.E. Andras, B. Hennig, and M. Toborek. PPARƒ¿ and PPARƒÁ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB Journal 23: 1596-606, 2009.

Majkova, Z., E.J. Smart, M. Toborek, and B. Hennig. Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicology and Applied Pharmacology 237: 1-7, 2009.

Owens, E.O., M. Toborek, and B. Hennig. Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene. Bulletin of Environmental Contamination and Toxicology 83: 4-7. 2009.

Zheng, Y.Y., E.J. Lim, L. Wang, E.J. Smart, M. Toborek, and B. Hennig. Role of caveolin-1 in EGCG-mediated protection against linoleic acid-induced endothelial cell activation. Journal of Nutritional Biochemistry 20: 202-209, 2009.

Lei W, Lim EJ, Toborek M, Hennig B. The role of fatty acids an d caveolin-1 in TNF-alpha-induced endothelial cell activation. Metabolism (in press)

Zheng YY, Lim EJ, Wang L, Smart EJ, Toborek M, Hennig B. Role of caveolin-1 in EGCG-mediated protection against linoleic acid-induced endothelial cell activation. J Nutr Biochem (in press)

András IE, Rha GB, Huang W, Eum SY, Couraud PO, Hennig B, Toborek M. Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells. Mol Pharmacol (in press)

Venkatachalam K, Arzuaga X, Chopra N, Gavalas VG, Xu J, Bhattacharyya D, Hennig B, Bachas LG. Reductive dechlorination of 3,3’,4,4’-tetrachloro biphenyl (PCB) using palladium or palladium/iron nanoparticles and assessment of the reduction in toxic potency in vascular endothelial cells. J Hazard Mater (in press)

 Lee, YW, Hennig B, Yao J, Toborek M. Methamphetamine induces AP-1 and NF-kappaB binding and transactivation in human brain endothelial cells. J. Neurosci. Res. (in press)

Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol. Sci. (in press)

András IE, Pu H, Tian J, Deli MA, Nath A, Hennig, B, Toborek M. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. Journal of Cerebral Blood Flow & Metabolism (J Cereb Blood Flow Metab). (in press)

Pu H, Tian J, András IE, Hayashi K, Flora G, Hennig B, Toborek M. HIV-1 TAT protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK1/2 activation. J Cereb Blood Flow Metab (in press)

Majkova Z, Oesterling E, Toborek M, and Hennig B. Impact of nutrition on PCB toxicity. Environ Toxicol Pharmacol, 25: 192-196, 2008.

 Shen H, Arzuaga X, Toborek M, and Hennig B. Zinc nutritional status modulates expression of AhR-responsive P450 enzymes in vascular endothelial cells. Environ Toxicol Pharmacol, 25: 197-201, 2008.

 Eum SY, Andras IE, Couraud PO, Hennig B, Toborek M. PCBs and tight junction expression. Environ Toxicol Pharmacol, 25: 234-240, 2008.

 Sipka S, Eum SY, Son KW, Xu S, Gavalas VG, Hennig B, Toborek M. Oral administration of PCBs induces proinflammatory and prometastatic responses. Environ Toxicol Pharmacol, 25: 251-259, 2008.

Wang L, Reiterer G, Toborek M, Hennig B.Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells.Chem Biol Interact, 172:27-38, 2008.

Pu H, Hayashi K, Andras IE, Eum SY, Hennig B, Toborek M. Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and discruption of the blood-brain barrier. Brain Res, 1184: 333-344, 2007.

Lim EJ, Smart E, Toborek M, Hennig B. The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells. Am J Physiol Heart Circ Physiol, 293: H3340-3347, 2007.

Arzuaga A, Reiterer G, Majkova Z, Kilgore MW, Toborek M, and Hennig B. Activation of PPARalpha reduces PCB-induced endothelial activation:possible interactions in inflammation and atherosclerosis. Cardiovasc Toxicol, 7:264-272,2007.

Shen H, MacDonald R, Bruemmer D, Stromberg A, Daugherty A, Li X, Toboreck M, and Hennig B. Zinc deficiency alters lipid metabolism in LDL-receptor-deficient mice treated with rosiglitazone J Nutr, 137: 2339-2345, 2007.

András IE, Deli M, Veszelka S, Hayashi K, Hennig B, Toborek M. The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells. J Cereb Blood Flow Metab, 27:1431-1443, 2007.

Umannova L, Zatloukalova J, Machala M, Krcmar P, Majkova Z, Hennig B, Kozubik A, Vondracek J. Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells. Toxicol Sci, 99:79-89, 2007.

Hennig B, Ettinger AS, Jandacek RJ, Koo S, McClain C, Seifried H, Silverstone A, Watkins B, Suk WA. Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ Health Perspect, 115:493-5, 2007.

Hennig B, Oesterling E, Toborek M. Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis. Nutr Metab Cardiovasc Dis, 17: 162-169, 2007.

Hennig B, Lei W, Arzuaga X, Das Ghosh D, Saraswathi V, Toborek M. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of the PI3K/Akt and ERK1/2 signaling. J Nutr Biochem, 17: 766-772, 2006.

Eum SY, Lee YW, Hennig B, Toborek M. Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced metalloproteinase-3 expression and transendothelial migration of tumor cells. Mol Cancer Res, 4: 361-370, 2006.

Eum SY, Rha GB, Hennig B, Toborek M. c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line. Toxicol Sci, 92: 311-320, 2006.

Hayashi K, Pu H, András IE, Eum SY, Yamauchi A, Hennig B, Toborek M. HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. Journal of Cerebral Blood Flow & Metabolism (JCBFM), 26: 1052-1065, 2006.

Flora G, Pu H, Hennig B, Toborek M. Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain. NeuroMolecular Med, 8: 337-351, 2006.

Reiterer G, Toborek M, Hennig B. Zinc and cell signaling during inflammation: implications in atherosclerosis. Current Nutrition & Food Science, 2: 23-28, 2006.

Hennig, B., M. Toborek, P. Ramadass, G. Ludewig, L.W. Robertson. Polychlorinated Biphenyls, Oxidative Stress and Diet. pp. 93-128. In: Reviews in Food and Nutrition Toxicity; edited by Preedy and Watson; CRC Press, Boca Raton, FL. 2005.

Flora, G., H. Pu, Y.W. Lee, R. Ravikumar, A. Nath, B. Hennig and M. Toborek. Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue. Experimental Neurology, 191: 2-12. 2005.

Hansen, L., M. Machala, L. Fischer, M. James, B. Hennig, H. Glauert, J.F. Narbonne, L. van Bree, T. Schultz, P. Grevatt, W. Suk, I. Holoubek, and L. Robertson. Research needs identified at the Second PCB Workshop in Brno, Czech Republic, May 7-11, 2002. Toxicological and Environmental Chemistry, 87: 261-265. 2005.

Hayashi, K., H. Pu, J. Tian, I.E. Andras, Y.W. Lee, B. Hennig and M. Toborek. HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells. Journal of Neurochemistry 93:1231-1241. 2005.

Hennig, B., G. Reiterer, Z. Majkova, E. Oesterling, P. Meerarani and M. Toborek. Modification of environmental toxicity by nutrients: implications in atherosclerosis. Cardiovascular Toxicology 5(2):153-60. 2005.

Hennig, B., G. Reiterer, M. Toborek, S.V. Matveev, A. Daugherty, E. Smart and L. Robertson. Dietary fat interacts with PCBs to induce changes in lipid metabolism in LDL receptor deficient mice. Environ.mental Health Perspectives 113: 83-87. 2005.

Reiterer, G., R. MacDonald, J.D. Browning, J. Marrow, S.V. Matveev, A. Daugherty, E. Smart, M. Toborek and B. Hennig. Zinc deficiency induces atherogenic events in LDL-R-deficient mice. Journal of Nutrition, 135:2114-2118. 2005.

Toborek, M., Y.W. Lee, G. Flora, H. Pu, I.E. Andras, E. Wylegala, B. Hennig and A. Nath. Mechanisms of blood-brain barrier disruption in HIV-1 infection. Cellular and Molecular Neurobiology 25: 181-199. 2005.

Lee, Y.W., S.Y. Eum, K.C. Chen, B. Hennig, and M. Toborek. Gene expression profile of interleukin-4-treated human vacular endothelial cells. Molecular Medicine 10(1-6):19-27. 2004.

Reiterer G, Toborek M, Meerarani P, Hennig B. Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells. J. Nutr. 134:1711-5, 2004

Reiterer G, Toborek M, Hennig B. Quercetin protects against linoleic acid-induced endothelial cell dysfunction without PPAR-gamma activation. J. Nutr., 134: 771-775, 2004.

Hennig B, Toborek M, Bachas LG, Suk WA. Emerging issues: Nutritional awareness in environmental toxicology. J. Nutr. Biochem., 15: 194-195, 2004.

Saraswathi V, Wu G, Toborek M, Hennig B. Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling. J. Lipid Res., 45: 794-804, 2004.

Ravikumar R, Flora G, Geddes JW, Hennig B, Toborek M. Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma. Brain Res Mol Brain Res., 124:188-98, 2004.

Eum SY, Lee YW, Hennig B, Toborek M. VEGF regulates PCB 104 mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells. Exp. Cell Res., 294: 231-44, 2004.

Chalimoniuk M, King-Pospisil K, Pedersen WA, Malecki A, Wylegala E, Mattson MP, Hennig B, Toborek M. Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism. J. Neurchem., 90: 629-36, 2004.

Lee, Y.W., Hennig B., Toborek M.. Redox-regulated mechanisms of interleukin-4-induced MCP-1 expression in human vascular endothelial cells. Am. J. Physiol., 284: H185-192, 2003.

Flora G., Lee Y.W., Nah A., Hennig B., Maragos W., Toborek M.. Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain. Exp. Neurol., 179, 60-70, 2003.

Toborek M., Lee Y.W., Pu H., Malecki A., Flora G., Garrido R., Hennig B., Bauer H.C., Nath A.. HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium. J. Neurochem., 84: 169-179, 2003.

Hennig B, Toborek M, Robertson LW. Nutrition and proinflammatory mechanisms of PCB toxicity in the vascular endothelium. Fresen. Environ. Bull., 12: 240-244, 2003.

Meerarani P, Smart EJ, Toborek M, Boissonneault GA, Hennig B. Cholesterol attenuates linoleic acid-induced endothelial cell activation. Metabolism, 52:493-500, 2003.

Lee, Y.W., H.J. Park, K.W. Son, B. Hennig, L.W. Robertson and M. Toborek. 2,2’4,4’,6’-Pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol. Appl. Pharmacol., 189: 1-10, 2003.

Meerarani P, Reiterer G, Toborek M, Hennig B. Zinc modulates PPAR-gamma signaling and activation of endothelial cells. J. Nutr., 133: 3049-3055, 2003.

Ramadass P, Meerarani P, Toborek M, Robertson LW, Hennig B. Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction and AhR DNA binding activity in vascular endothelial cells. Toxicol. Sci., 76: 212-219, 2003.

Garrido R, King-Pospisil K, Son KW, Hennig B, Toborek M. Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons. Neurosci. Res., 47: 349-355, 2003.

Pu H, Tian J, Flora G, Lee YW, Nath A, Hennig B, Toborek M: HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol. Cell. Neurosci., 24: 224-237, 2003.

Garrido R, Springer JE, Hennig B, Toborek M. Nicotine attenuates arachidonic acid-induced apoptosis of spinal cord neurons by preventing depletion of neurotrophic factors. J. Neurotrauma, 20: 1201-1213, 2003.

Saraswathi V, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. J. Am. Coll. Nutr., 502-510, 2003.

András IE, Pu H, Deli MA, Nath A, Hennig B, Toborek M. HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J. Neurosci. Res., 74: 255-265, 2003.

Toborek, M., Y.W. Lee, R. Garrido, S. Kaiser, and B. Hennig. Dietary unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am. J. Clin. Nutr., 75: 119-125. 2002.

Park, H.J., Y.W. Lee, B. Hennig, and M. Toborek. Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. Nutr. Cancer, 41: 126-134, 2002.

Toborek, M., Y.W. Lee, S. Kaiser, and B. Hennig. Measurement of inflammatory properties of fatty acids in human endothelial cells. Methods Enzymol., 352: 198-219, 2002.

Hennig, B., Hammock B.D., R. Slim, M. Toborek, V. Saraswathi, and L.W. Robertson. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int. J. Hyg. Environ. Health, 205: 95-102, 2002.

Hennig, B., P. Meerarani, R. Slim, M. Toborek, A. Daugherty, A. Silverstone, and L.W. Robertson. Proinflammatory properties of co-planar PCBs: in vitro and in vivo evidence. Toxicol. Appl. Pharmacol., 181: 174-183, 2002.

Flora, G., Y.W. Lee, A. Nath, W. Maragos, B. Hennig and M. Toborek. Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation. J. Molec. Neurosci. 2: 71-85, 2002.

Lee, Y.W., K.W. Son, G. Flora, B. Hennig, A. Nath and M. Toborek. Methamphetamine activates DNA-binding of specific redox-responsive transcription factors in mouse brain. J. Neurosci. Res., 70: 82-89, 2002.

Lee YW, Hennig B, Fiala M, Toborek M. Cocaine activates redox-regulated transcription factors and induces TNF-alpha expression in human brain endothelial cells. Brain Res, 920: 125-133, 2001.

Lee YW, Park HJ, Hennig B, Toborek M. Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism.  J Nutr Biochem, 12: 648-654, 2001.

Lee YW, Kühn H, Kaiser S, Hennig B, Daugherty A, Toborek M. Interleukin-4 induces transcription of the 15-lipoxygenase-I gene in human endothelial cells. J Lipid Res, 42: 783-791, 2001.

Hennig B, Toborek M, McClain CJ. High-energy nutrients, fatty acids and endothelial cell function: implications in atherosclerosis. J Am Coll Nutr, 20: 97-105, 2001.

Garrido R, Mattson MP, Hennig B, Toborek M. Nicotine protects against arachidonic acid-induced caspase activation, cytochrome c release, and apoptosis of cultured spinal cord neurons. J Neurochem, 76: 1395-1403, 2001.

Hennig B, Toborek M. Nutrition and Endothelial Cell Function: implications in Atherosclerosis. Nutr Res, 21: 279-293, 2001.

Slim R, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau CHP, Watkins BA, Saraswathi V, Hennig B. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol, 171: 184-193, 2001.

Lee YW, Kühn H, Hennig B, Neish AS, Toborek M. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J Mol Cell Cardiol, 33: 83-94, 2001.

Lee YW, Kühn H, Hennig B, Toborek M. IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway. FEBS Lett, 485: 122-126, 2000.

Krizbai IA, Bauer H, Amberger A, Hennig B, Szabo H, Fuchs R, Bauer HC. Growth factor-induced morphological, physiological and molecular characteristics in cerebral endothelial cells. Eur J Cell Biol, 79: 594-600, 2000.

Hennig B, Meerarani P, Ramadass P, Watkins BA, Toborek M. Fatty acid-mediated activation of vascular endothelial cells. Metabolism, 49: 1006-1013, 2000.

Hennig B, Slim R, Toborek M, Malecki A, Robertson LW. Effects of lipids and antioxidants on PCB-mediated dysfunction of vascular endothelial cells. Cent Eur J Public Health, 8 Suppl: 18-19, 2000.

Slim R, Toborek M, Robertson LW, Lehmler HJ, Hennig B. Cellular glutathione status modulates polychlorinated biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol, 166: 36-42, 2000.

Malecki A, Garrido R, Mattson MP, Hennig B, Toborek M. 4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons. J Neurochem, 74: 2278-2287, 2000.

Garrido R, Malecki A, Hennig B, Toborek M. Nicotine attenuates arachidonic acid-induced neurotoxicity in cultured spinal cord neurons. Brain Res, 861: 59-68, 2000.

Toborek M, Garrido R, Malecki A, Kaiser S, Mattson MP, Hennig B, Young B. Nicotine attenuates arachidonic acid-induced overexpression of nitric oxide synthase in cultured spinal cord neurons. Exp Neurol, 161: 609-620, 2000.

Slim R, Toborek M, Robertson LW, Hennig B. Antioxidant protection against PCB-mediated endothelial cell activation. Toxicol Sci, 52: 232-239, 1999.

Meerarani P, Ramadass P, Toborek M, Bauer HC, Bauer H, Hennig B. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Am J Clin Nutr, 71: 81-87, 2000.

Lab Personnel (photos)